Bromine → HCID 87322888, compound

HRID 2425278Notes

Reaction equation

HRID 2425278 reaction equation
[Br:1]Br.[F:3][C:4]([C:14]([F:32])([F:31])[C:15]([F:30])([F:29])[C:16]([F:28])([F:27])[C:17]([F:26])([F:25])[C:18]([F:24])([F:23])[C:19]([F:22])([F:21])[F:20])([C:6]1[S:7][C:8](F)=[C:9]([F:12])[C:10]=1[F:11])[OH:5].C([O-])(O)=O.[Na+]>C(Cl)Cl>[F:3][C:4]([C:14]([F:32])([F:31])[C:15]([F:30])([F:29])[C:16]([F:28])([F:27])[C:17]([F:26])([F:25])[C:18]([F:24])([F:23])[C:19]([F:22])([F:21])[F:20])([C:6]1[S:7][C:8]([Br:1])=[C:9]([F:12])[C:10]=1[F:11])[OH:5]

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 87322988HCID 87322988, compound

Product 1

HCID 87322888HCID 87322888, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bromine (0.698 g) was added to a solution of 1 (1.80 g, 4.16 mmol) in CH2Cl2 (15 mL). After stirring overnight at room temperature, the mixture was neutralized with saturated aqueous NaHCO3 solution and extracted with CH2Cl2 (3×20 mL). The organic layers were combined, dried over MgSO4, and concentrated in vacuo (1.90 g, 89%).

Workup

  1. extractionextracted with CH2Cl2 (3×20 mL)
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo (1.90 g, 89%)

Sources & evidence

ORD record
ord-1bf150cb8bcc4bca9ee0d4d1daf9f398
Source dataset
uspto-grants-2011_06
Patent number
US07964650B2

Reaction notes

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