Lithium Hydroxide → HCID 67246991, compound

HRID 2425320Notes

Reaction equation

HRID 2425320 reaction equation
[OH:1][CH2:2][C:3]([NH:23]C(=O)C)([CH2:21][OH:22])[CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:10]=2)[CH2:5]1.[Li+].[OH-]>CO>[NH2:23][C:3]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:10]=2)[CH2:5]1)([CH2:21][OH:22])[CH2:2][OH:1]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67246215HCID 67246215, compound

Product 1

HCID 67246991HCID 67246991, compoundYield 37.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 6 (8 mg, 0.022 mmol) in MeOH (0.1 mL) was added LiOH (0.01 g, 0.154 mmol). The reaction was refluxed for 2 hours. The resulting solution was concentrated and purified with silica gel chromatography eluding with 75% MeOH and 25% CH2Cl2. The reaction provided 7 (2.6 mg, 0.00822 mmol, 37%).

Workup

  1. temperatureThe reaction was refluxed for 2 hours
  2. concentrationThe resulting solution was concentrated
  3. custompurified with silica gel chromatography

Sources & evidence

ORD record
ord-575616bdb6ac447dbe881e2ce54057fe
Source dataset
uspto-grants-2011_06
Patent number
US07964649B2

Reaction notes

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