Hydrochloric Acid → HCID 67248603, compound

HRID 2425321Notes

Reaction equation

HRID 2425321 reaction equation
Cl.C([O:4][C:5](=[O:33])[C:6]([NH:29]C(=O)C)([CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:18]=2)[CH2:13]1)C(OCC)=O)C>CO>[NH2:29][CH:6]([CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:18]=2)[CH2:13]1)[C:5]([OH:33])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67245862HCID 67245862, compound

Product 1

HCID 67248603HCID 67248603, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 10 mL of 12 M hydrochloric acid was added 5 (0.2 g, 0.451 mmol). Methanol was added until mix became homogenous and solution was allowed to reflux for 2 hours. The resulting mix was concentrated and co-evaporated with methanol and ether (3×10 mL). The reaction provided 10 (63 mg, 0.2076 mmol, 46%).

Workup

  1. additionuntil mix
  2. temperatureto reflux for 2 hours
  3. additionThe resulting mix
  4. concentrationwas concentrated and co-evaporated with methanol and ether (3×10 mL)

Sources & evidence

ORD record
ord-9f0279c81d9e423ba120dbd6e5d22e4f
Source dataset
uspto-grants-2011_06
Patent number
US07964649B2

Reaction notes

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