tert-butyl N-(pyrrolidin-3-yl)carbamate → Hydrochloric Acid

HRID 2425440Notes

Reaction equation

HRID 2425440 reaction equation
BrC1C2C(S([Cl:15])(=O)=O)=CC=CC=2C=NC=1.C(OC(NC1CCNC1)=O)(C)(C)C.C(OC([NH:36][CH2:37][CH:38]1[CH2:41][N:40]([S:42]([C:45]2[C:46]3[C:47]([Cl:55])=[CH:48][N:49]=[CH:50][C:51]=3[CH:52]=[CH:53][CH:54]=2)(=[O:44])=[O:43])[CH2:39]1)=O)(C)(C)C>>[NH2:36][CH2:37][CH:38]1[CH2:39][N:40]([S:42]([C:45]2[C:46]3[C:47]([Cl:55])=[CH:48][N:49]=[CH:50][C:51]=3[CH:52]=[CH:53][CH:54]=2)(=[O:43])=[O:44])[CH2:41]1.[ClH:15]

Participants

5

Reactant 3

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 145800584-Bromo-5-isoquinolinesulfonyl chlorideHCID 67243257HCID 67243257, compound

Product 2

HCID 313Hydrochloric AcidHCID 67244881HCID 67244881, compound

Procedure

4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 and 3-(tert-butoxycarbonylaminomethyl)azetidine were used in the method of Example 1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and 3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to prepare 3-[(tert-butoxycarbonylamino)methyl]-1-(4-chloro-5-isoquinolinesulfonyl)azetidine, and then the resultant was used in the method of Example 1, Step B to obtain the title compound as hydrochloride.

Sources & evidence

ORD record
ord-1cdf5f03de7b4d20af38b591437efc51
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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