Hydrochloric Acid → HCID 57580034, compound

HRID 2425445Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH:17][C@H:18]2[CH2:22][CH2:21][N:20]([S:23]([C:26]3[C:27]4[C:28]([Cl:36])=[CH:29][N:30]=[CH:31][C:32]=4[CH:33]=[CH:34][CH:35]=3)(=[O:25])=[O:24])[CH2:19]2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C(OC(N1CCN(CC(O)=O)CC1)=O)(C)(C)C.COCC(O)=O>>[N:11]1([CH2:14][C:15]([NH:17][C@@H:18]2[CH2:22][CH2:21][N:20]([S:23]([C:26]3[C:27]4[C:28]([Cl:36])=[CH:29][N:30]=[CH:31][C:32]=4[CH:33]=[CH:34][CH:35]=3)(=[O:25])=[O:24])[CH2:19]2)=[O:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 12251Methoxyacetic Acid

HCID 27356422-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}acetic acid

HCID 67242584HCID 67242584, compound

Product 1

HCID 57580034HCID 57580034, compound

Procedure

(S)-3-[2-[4-(tert-butoxycarbonyl)piperazin-1-yl]acetyl]amino-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine can be prepared from hydrochloride of the compound prepared in Example 19-2 by using 2-[4-(tert-butoxycarbonyl)piperazin-1-yl]acetic acid in the method of Example 56-1 instead of 2-methoxyacetic acid, and the protective group of the obtained compound can be removed according to the method described in Example 1-1, Step B to obtain the title compound.

Workup

customthe protective group of the obtained compound can be removed

Sources & evidence

ORD record: ord-a01d2cb8b814416383a6d0e6ba1ee748
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964613B2

Reaction notes

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