Trifluoroacetic acid → Trifluoroacetate

HRID 2425452Notes

Reaction equation

HRID 2425452 reaction equation
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][O:5][CH2:6][C:7]([NH:9][C@H:10]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1)=[O:8].[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][O:5][CH2:6][C:7]([NH:9][C@H:10]1[CH2:14][CH2:13][NH:12][CH2:11]1)=[O:8].[F:23][C:24]([F:29])([F:28])[C:25]([O-:27])=[O:26]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67243468HCID 67243468, compound

Product 2

HCID 84468TrifluoroacetateHCID 67242571HCID 67242571, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-3-[2-[2-(Dimethylamino)ethoxy]acetyl]amino-1-(tert-butoxycarbonyl)pyrrolidine (175 mg) prepared in Step D was added with a 30% solution of trifluoroacetic acid in dichloromethane (5 ml), and the mixture was stirred at room temperature. The volatile components were removed to obtain the title compound as trifluoroacetate (246 mg).

Workup

  1. customThe volatile components were removed

Sources & evidence

ORD record
ord-cbed5dbaa1b642018138ce975f0fc9eb
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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