反应详情

A solution of azetidine hydrochloride (1 g, Aldrich) in a mixture of tetrahydrofuran (20 ml) and water (5 ml) was added with 2 N aqueous sodium hydroxide (10.7 ml) at 0° C., and then gradually added with tert-butyl bromoacetate (1.052 ml), and the mixture was stirred at the same temperature for 10 minutes, and further stirred at room temperature for 45 minutes. The reaction mixture was added with water and ethyl acetate, and the organic layer was separated. The aqueous layer was extracted three times with ethyl acetate, the combined organic layer was washed three times with saturated brine, and the solvent was evaporated under reduced pressure to obtain the title compound (688 mg).

1. stirringfurther stirred at room temperature for 45 minutes
2. customthe organic layer was separated
3. extractionThe aqueous layer was extracted three times with ethyl acetate
4. washthe combined organic layer was washed three times with saturated brine
5. customthe solvent was evaporated under reduced pressure