Hydrochloric Acid → HCID 67246199, compound

HRID 2425751Notes

Reaction equation

HRID 2425751 reaction equation
[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)[CH2:21][CH2:20]2)=[O:16])[C:5]1=[O:39])([CH3:3])[CH3:2].[ClH:40]>>[ClH:40].[ClH:40].[CH:1]([N:4]1[C:13]2[C:8](=[C:9]([CH3:14])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]3)[CH2:21][CH2:20]2)=[O:16])[C:5]1=[O:39])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59822474HCID 59822474, compound

Product 1

HCID 67246199HCID 67246199, compoundYield 96%

Procedure

tert-Butyl 4-{[4-({[(1-isopropyl-5-methyl-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}methyl)piperidine-1-yl]methyl}piperidine-1 carboxylate (150 mg, 0.28 mmol, step 1) was dissolved in 10% methanolic hydrogen chloride (20 mL) and the mixture was stirred for 16 h at room temperature. The mixture was concentrated to give yellow oil, which was crystallized from diethyl ether and n-hexane. The solid was collected by filtration to give 110 mg (96%) of the title compound as a pale yellow solid.

Workup

  1. concentrationThe mixture was concentrated
  2. customto give yellow oil, which
  3. customwas crystallized from diethyl ether and n-hexane
  4. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-c18620eb271d4778aff0b3c700372f60
Source dataset
uspto-grants-2011_06
Patent number
US07964727B2

Reaction notes

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