Hydrochloric Acid → HCID 59257846, compound

HRID 2426211Notes

Reaction equation

HRID 2426211 reaction equation
[CH3:1][N:2]1[C:14]2[C:15]3[CH:7]([CH2:8][N:9]([CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[C:10]=3[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][C:3]1=[O:24].Cl>CCOC(C)=O>[CH3:1][N:2]1[C:14]2[C:15]3[CH:7]([CH2:8][N:9]([CH2:16][C:17]([OH:19])=[O:18])[C:10]=3[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][C:3]1=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 86622847HCID 86622847, compound

Product 1

HCID 59257846HCID 59257846, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl (7-methyl-6-oxo-2a,3,4,5,6,7-hexahydroazocino[4,3,2-cd]indol-1(2H)-yl)acetate, enantiomer A, from Step G (18 mg, 0.057 mmol) in EtOAc (1 mL) was saturated with HCl (g), aged at ambient temperature for 10 min, then resaturated with HCl (g). After a further 10 min, the mixture was concentrated in vacuo to give the title compound. MS: m/z=275 (M+1).

Workup

  1. waitAfter a further 10 min
  2. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-023003b7f71b4d9194d1b9ad106d0e09
Source dataset
uspto-grants-2011_06
Patent number
US07968540B2

Reaction notes

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