Ethyl Acetate → 6-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline

HRID 2426286Notes

Reaction equation

HRID 2426286 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:22]=[CH:21][C:17]3[O:18][CH2:19][O:20][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2].[CH3:23]COC(C)=O>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:22]=[CH:21][C:17]3[O:18][CH2:19][CH2:23][O:20][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 578631566-Nitro-2-(1,3-benzodioxole-5-yl)-quinazoline

Product 1

HCID 578631426-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazolineYield 70%

Procedure

This compound was synthesized in 70% yield, according to the procedure described in example 1 for the synthesis of 6-nitro-2-(1,3-benzodioxole-5-yl)-quinazoline. C16H11N3O4, MW: 309.28. mp. 263-265° C.; TLC (tol/AcOEt 7/3) Rf=0.80.

Workup

  1. customThis compound was synthesized in 70% yield

Sources & evidence

ORD record
ord-e2d2544204e8477196eb619b4ff8ba88
Source dataset
uspto-grants-2011_06
Patent number
US07968558B2

Reaction notes

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