Hydrochloric Acid → HCID 178465557, compound

HRID 2426287Notes

Reaction equation

HRID 2426287 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:13]=[CH:14][C:15]3[O:19][CH2:18][CH2:17][C:16]=3[CH:20]=1)[N:6]=[CH:5]2.[ClH:21]>CC#N>[OH2:19].[ClH:21].[ClH:21].[O:19]1[C:15]2[CH:14]=[CH:13][C:12]([C:7]3[N:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([NH:1][C:2](=[NH:1])[CH3:11])[CH:3]=4)[N:8]=3)=[CH:20][C:16]=2[CH2:17][CH2:18]1.[O:19]1[C:15]2[CH:14]=[CH:13][C:12]([C:7]3[N:6]=[CH:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([NH:1][C:5](=[NH:6])[CH3:4])[CH:3]=4)[N:8]=3)=[CH:20][C:16]=2[CH2:17][CH2:18]1.[ClH:21].[ClH:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 578631616-Amino-2-(2,3-dihydro-5-benzofuryl)-quinazoline

Product 1

HCID 178465557HCID 178465557, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 6-amino-2-(2,3-dihydro-5-benzofuryl)-quinazoline (1.4 g, 0.0053 mol) in MeCN (50 ml) was satured with HCl at 0° C. and stirred at r.t. for 24 hrs. The precipitated was filtered and triturated with acetone/methanol. The light yellow solid was filtered and dried in vacuum at 40° C. to give the titled compound, 1.3 g, 65% yield).

Workup

  1. filtrationThe precipitated was filtered
  2. customtriturated with acetone/methanol
  3. filtrationThe light yellow solid was filtered
  4. customdried in vacuum at 40° C.

Sources & evidence

ORD record
ord-8339dcabc173453f90ca4090ced228fe
Source dataset
uspto-grants-2011_06
Patent number
US07968558B2

Reaction notes

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