Diethyl Ether → 2(S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propionic acid

HRID 2426323Notes

Reaction equation

HRID 2426323 reaction equation
S(OC)(O[CH3:5])(=O)=O.[NH2:8][C:9]1[N:10]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C@H:22]([O:27][CH2:28][CH3:29])[C:23]([O:25][CH3:26])=[O:24])=[CH:17][CH:16]=2)[N:12]([CH3:14])[N:13]=1.[CH2:30](OCC)C>C(N(CC)CC)C.O1CCCC1>[CH2:28]([O:27][C@@H:22]([CH2:21][C:18]1[CH:17]=[CH:16][C:15]([C:11]2[N:12]([CH3:14])[N:13]=[C:9]([NH:8][CH3:5])[N:10]=2)=[CH:20][CH:19]=1)[C:23]([O:25][CH3:26])=[O:24])[CH3:29].[CH2:28]([O:27][C@@H:22]([CH2:21][C:18]1[CH:19]=[CH:20][C:15]([C:11]2[N:12]([CH3:14])[N:13]=[C:9]([NH:8][CH3:30])[N:10]=2)=[CH:16][CH:17]=1)[C:23]([OH:25])=[O:24])[CH3:29]

Participants

7

Reactant 3

HCID 3283Diethyl EtherHCID 6497Dimethyl Sulfate2×HCID 67147868methyl 3-[4-(5-amino-2-methyl-2H-[1,2,4]triazol-3-yl)phenyl]-2(S)-ethoxypropanoate

Product 2

HCID 67147916methyl 2(S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propanoateYield 16%HCID 671481032(S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propionic acidYield 60%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8471TriethylamineSolvent2×

Conditions

Temperature
35 °C

Procedure

0.2 ml (2.2 mmol) of dimethyl sulfate is added to a mixture of 0.6 g (2 mmol) of methyl 3-[4-(5-amino-2-methyl-2H-[1,2,4]triazol-3-yl)phenyl]-2(S)-ethoxypropanoate, 0.3 ml (2.2 mmol) of triethylamine and 40 ml of ethyl ether. The reaction medium is heated at 35° C. for 4 hours. The reaction changed very little, 20 ml of tetrahydrofuran, 0.3 ml of triethylamine and 0.2 ml (2.2 mmol) of dimethyl sulfate are added and the reaction medium is heated at 40° C. for a further 24 hours. The reaction medium is evaporated to dryness. The residue obtained is purified by thin-layer chromatography on silica eluted with a 97/3 and then 95/5 dichloromethane/methanol mixture. 0.1 g (16%) of methyl 2(S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propanoate and 0.4 g (60%) of 2(S)-ethoxy-3-[4-(2-methyl-5-methylamino-2H-[1,2,4]triazol-3-yl)phenyl]propionic acid are obtained.

Workup

  1. temperaturethe reaction medium is heated at 40° C. for a further 24 hours
  2. customThe reaction medium is evaporated to dryness
  3. customThe residue obtained
  4. customis purified by thin-layer chromatography on silica
  5. washeluted with a 97/3

Sources & evidence

ORD record
ord-ca4f68ad94264d1babdfdcff1b90129c
Source dataset
uspto-grants-2011_06
Patent number
US07968560B2

Reaction notes

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