Pyridine → HCID 178433931, compound

HRID 2426531Notes

Reaction equation

HRID 2426531 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([NH:10][NH2:11])=O)=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:4][NH:3]1.[C:18]([NH2:21])(=S)[CH3:19].C(N(CC)CC)C.N1C=CC=CC=1>C(O)CCC>[CH3:19][C:18]1[NH:21][C:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[CH:6]=2)=[N:10][N:11]=1

Participants

6

Reactant 4

HCID 1049PyridineHCID 8471TriethylamineHCID 2723949ThioacetamideHCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

Product 1

HCID 178433931HCID 178433931, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 100 mg of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid hydrazide, 130 mg thioacetamide, 87 mg triethylamine, 1 ml of pyridine and 5 ml of butanol is refluxed for 15 hours. After cooling and stirring at room temperature, a solid precipitated is collected by filtration, washed with cold isopropanol and dried in vacuo.

Workup

  1. temperatureis refluxed for 15 hours
  2. temperatureAfter cooling
  3. customa solid precipitated
  4. filtrationis collected by filtration
  5. washwashed with cold isopropanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-dea1626f743442bca9d01c461decd5ef
Source dataset
uspto-grants-2011_06
Patent number
US07968546B2

Reaction notes

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