4-Methylpiperidine → HCID 21105503, compound

HRID 2426729Notes

Reaction equation

HRID 2426729 reaction equation
FC(F)(F)S(O[C:7]1[CH:8]=[CH:9][C:10]([C:13]([O:15]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:14])=[N:11][CH:12]=1)(=O)=O.[CH3:31][CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH3:31][CH:32]1[CH2:37][CH2:36][N:35]([C:7]2[CH:12]=[N:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 693814-MethylpiperidineHCID 10873809HCID 10873809, compound

Product 1

HCID 21105503HCID 21105503, compound

Procedure

Benzhydryl 5-trifluoromethanesulfonyloxypyridine-2-carboxylate (3.0 g) was heated with 4-methylpiperidine (1.4 g) at 80° C. for one hour. The reaction mixture was immediately purified by preparative HPLC and then hydrogenated in analogy to method. This resulted in the product with the molecular weight of 220.27 (C12H16N2O2); MS (ESI): 221 (M+H+).

Workup

  1. customThe reaction mixture was immediately purified by preparative HPLC
  2. customThis resulted in the product with the molecular weight of 220.27 (C12H16N2O2)

Sources & evidence

ORD record
ord-b93afa666fdf435a854a82aa9dd3f020
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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