Aluminium lithium hydride → [4'-(Methanesulfonyl)[1,1'-biphenyl]-3-yl]methanol

HRID 2426751Notes

Reaction equation

HRID 2426751 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17](OC)=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][OH:18])[CH:12]=2)=[CH:9][CH:10]=1)(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57787810HCID 57787810, compound

Product 1

HCID 20100324[4'-(Methanesulfonyl)[1,1'-biphenyl]-3-yl]methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In an atmosphere of nitrogen, under ice-cooling, methyl 4′-(methylsulfonyl)biphenyl-3-carboxylate was added to a THF suspension of lithium aluminum hydride, followed by stirring for 20 minute to obtain [4′-(methylsulfonyl)biphenyl-3-yl]methanol.

Workup

  1. temperatureIn an atmosphere of nitrogen, under ice-cooling

Sources & evidence

ORD record
ord-5091657163d94514ae2854921c0f0b86
Source dataset
uspto-grants-2011_06
Patent number
US07968552B2

Reaction notes

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