反应详情

In an atmosphere of nitrogen, sodium hydride was added under ice-cooling to a THF solution of (2′,6′-dimethylbiphenyl-3-yl)methanol, followed by stirring at that temperature for 15 minutes. Thereafter, 6-chloronicotinonitrile was added to the reaction mixture under ice-cooling, followed by warming up to room temperature and stirring for 3 hours to obtain 6-[(2′,6′-dimethylbiphenyl-3-yl)methoxy]nicotinonitrile.

1. temperaturecooling
2. stirringstirring for 3 hours