HCID 57787091, compound → HCID 67252107, compound

HRID 2426766Notes

Reaction equation

HRID 2426766 reaction equation
[CH3:1][Mg]I.[OH:4][CH2:5][C:6]1[CH:32]=[CH:31][C:9]([O:10][CH2:11][C:12]2[CH:13]=[C:14]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([O:25][CH2:26][C:27]([CH3:29])=[O:28])=[CH:20][C:19]=3[CH3:30])[CH:15]=[CH:16][CH:17]=2)=[CH:8][CH:7]=1>C1COCC1>[OH:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][C:12]2[CH:13]=[C:14]([C:18]3[C:19]([CH3:30])=[CH:20][C:21]([O:25][CH2:26][C:27]([CH3:1])([OH:28])[CH3:29])=[CH:22][C:23]=3[CH3:24])[CH:15]=[CH:16][CH:17]=2)=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 57787091HCID 57787091, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 67252107HCID 67252107, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In an atmosphere of nitrogen, a THF solution of methylmagnesium iodide was dropwise added under ice-cooling to a THF solution of 1-[(3′-{[4-(hydroxymethyl)phenoxy]methyl}-2,6-dimethylbiphenyl-4-yl)oxy]acetone, followed by stirring at room temperature for 30 minute to obtain 1-[(3′-{[4-(hydroxymethyl)phenoxy]methyl}-2,6-dimethylbiphenyl-4-yl)oxy]-2-methylpropan-2-ol.

Sources & evidence

ORD record
ord-d5f4c59bf3e245af9962094f1cc7ae95
Source dataset
uspto-grants-2011_06
Patent number
US07968552B2

Reaction notes

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