反应详情

温度

60 °C

A 1 M sodium hydroxide aqueous solution (5 ml) was added to a mixture of methyl 3′-({4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phenoxy}methyl)-4-biphenylcarboxylate (196 mg), methanol (5 ml) and THF (5 ml), followed by stirring for 1 hour with heating at 60° C. A 1 M hydrochloric acid (7 ml) was added to the reaction mixture, followed by stirring at room temperature. The solid precipitated was collected by filtration and dried by heating under a reduced pressure to obtain 3′-({4-[(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)methyl]phenoxy}methyl)-4-biphenylcarboxylic acid (176 mg) as a white solid.

1. stirringby stirring at room temperature
2. customThe solid precipitated
3. filtrationwas collected by filtration
4. customdried
5. temperatureby heating under a reduced pressure