Lithium hydroxide, monohydrate → HCID 86639850, compound

HRID 2426969Notes

Reaction equation

HRID 2426969 reaction equation
[OH:1][C@@:2]([CH3:11])([CH2:9][OH:10])[C:3](N(OC)C)=[O:4].[OH2:12].[OH-].[Li+:14]>CO>[OH:1][C@@:2]([CH3:11])([CH2:9][OH:10])[C:3]([O-:4])=[O:12].[Li+:14]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 11480618(2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide

Product 1

HCID 86639850HCID 86639850, compoundYield 102.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the compound prepared in Example 130(a) (565 mg) in methanol (7.0 mL) was added lithium hydroxide monohydrate (146 mg) and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated to give the title compound (446 mg) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-640a161f041a452882254f3fe9009af5
Source dataset
uspto-grants-2011_06
Patent number
US07968572B2

Reaction notes

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