Dimethylformamide → HCID 86639852, compound

HRID 2426975Notes

Reaction equation

HRID 2426975 reaction equation
[CH3:1][C@@:2]1([C:8]([OH:10])=O)[CH2:6][O:5][C:4](=[O:7])[O:3]1.C(Cl)(=O)C([Cl:14])=O.CN(C=O)C>ClCCl>[CH3:1][C@@:2]1([C:8]([Cl:14])=[O:10])[CH2:6][O:5][C:4](=[O:7])[O:3]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 55302368HCID 55302368, compound

Product 1

HCID 86639852HCID 86639852, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound prepared in Example 184 (330 mg) in dichloromethane (11 mL) were added oxalyl chloride (290 μL) and DMF (0.1 mL) and the reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated in vacuum condition to give the title compound (2.0 g) having the following physical data as a coarse product. This compound was used for the next reaction without being purified.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuum condition

Sources & evidence

ORD record
ord-e9c5f8387e5047f3aad8142c1bc06a55
Source dataset
uspto-grants-2011_06
Patent number
US07968572B2

Reaction notes

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