反应详情

A mixture of the product of Step 1 (0.1 g) and LiOH (3 mL, 1N) in 15 mL of 1:1:1 THF/MeOH/H2O was stirred for two days at room temperature and heated at 55° C. for 20 h. The mixture was cooled and treated with 5 mL of 1N HCl, followed by extraction with 30 mL of EtOAc. The EtOAc extract was dried over Na2SO4, filtered and concentrated to give the crude product (0.1 g) which was used for next step without further purification.

1. temperatureheated at 55° C. for 20 h
2. temperatureThe mixture was cooled
3. extractionfollowed by extraction with 30 mL of EtOAc
4. extractionThe EtOAc extract
5. dry with materialwas dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated