反应详情

To a solution of 0.86 g of 4-[2,5-dioxo-4-phenyl-4-[(2-propenyloxy)methyl]imidazolidin-1-yl]-2-trifluoromethyl-benzonitrile and 0.26 mL of iodomethane in 30 mL of DMF is added 430 mg of potassium carbonate. The mixture is stirred at rt for 5 hours, evaporated to dryness, diluted with water and extracted with ethyl acetate. The organic layer is dried over magnesium sulfate, filtered and evaporated. The crude product is purified by chromatography over silica gel while eluting with 70/30 heptane/ethyl acetate mixture to provide the desired product.

1. customevaporated to dryness
2. additiondiluted with water
3. extractionextracted with ethyl acetate
4. dry with materialThe organic layer is dried over magnesium sulfate
5. filtrationfiltered
6. customevaporated
7. customThe crude product is purified by chromatography over silica gel
8. washwhile eluting with 70/30 heptane/ethyl acetate mixture