Sodium hydride → HCID 22148876, compound

HRID 2427211Notes

Reaction equation

HRID 2427211 reaction equation
[SH:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:5]=2[N:6]=1.Cl[C:16]1[C:21]([Cl:22])=[CH:20][C:19]([N+:23]([O-:25])=[O:24])=[CH:18][C:17]=1[C:26](=[O:28])[CH3:27].[H-].[Na+]>CN(C=O)C>[Cl:22][C:21]1[C:16]([S:1][C:2]2[S:3][C:4]3[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:5]=3[N:6]=2)=[C:17]([C:26](=[O:28])[CH3:27])[CH:18]=[C:19]([N+:23]([O-:25])=[O:24])[CH:20]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 221487381-(2,3-Dichloro-5-nitro-phenyl)-ethanoneHCID 1784190875-(trifluoromethyl)-1,3-benzothiazole-2-thiol

Product 1

HCID 22148876HCID 22148876, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared using the method of example 258, starting with 5-trifluoromethyl-benzothiazole-2-thiol (239) (470 mg, 2.0 mmol), 1-(2,3-dichloro-5-nitro-phenyl)-ethanone (248) (466 mg, 2.0 mmol) and NaH (Aldrich, 60% suspension, 80 mg, 2.0 mmol) in DMF (20 mL). Compound 259 (750 mg, 87%) was obtained as a yellow solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-79bcd352d4364c27bb6eb96c3388941f
Source dataset
uspto-grants-2011_06
Patent number
US07968567B2

Reaction notes

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