反应详情

温度

90 °C

0.5M solution of 1-bromomethyl-4-trifluoromethyl-benzene (1.9 g, 8.0 mmol) in DMF was added dropwise to a suspension of 4-hydroxy-3,5-dimethyl-benzaldehyde (930 mg, 7.3 mmol), K2CO3 (1.51 g, 11 mmol) and KI (120 mg, 0.73 mmol) in DMF (100 ml). The reaction mixture was stirred at 90° C. overnight. After cooling, the solid residue was filtered off and the solvent was evaporated under vacuum. The residue was dissolved in ethyl acetate and the organic layer washed twice with NaOH 1M, dried over Na2SO4 and evaporated to dryness. The residue was purified on silica gel, obtaining 2.24 g of the title compound in a quantitative yield.

1. temperatureAfter cooling
2. filtrationthe solid residue was filtered off
3. customthe solvent was evaporated under vacuum
4. dissolutionThe residue was dissolved in ethyl acetate
5. washthe organic layer washed twice with NaOH 1M
6. dry with materialdried over Na2SO4
7. customevaporated to dryness
8. customThe residue was purified on silica gel