反应详情

温度

100 °C

A mixture of 2-bromomethyl-6-iodo-benzoic acid methyl ester (0.150 g, 0.42 mmol), 3-(3-fluoro-phenyl)-propylamine (0.091 mL, 0.6 mmol), and K2CO3 (0.138 g, 1 mmol) in toluene (5 mL) was heated with stirring at 100° C. for 2 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 2-[3-(3-fluoro-phenyl)-propyl]-7-iodo-2,3-dihydro-isoindol-1-one (0.110 g, 69%). 1H NMR (300 MHz, CDCl3): δ ppm) 2.01 (m, 2H), 2.72 (t, 2H), 3.66 (t, 2H), 4.25 (s, 2H), 6.82-7.24 (m, 5H), 7.41 (d, 1H), 7.92 (d, 1H).

1. temperaturewas heated