6-Amino-1-hexanol → HCID 67262989, compound

HRID 2428273Notes

Reaction equation

HRID 2428273 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][OH:38]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][OH:38])=[O:16])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 199606-Amino-1-hexanolHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 67262989HCID 67262989, compoundYield 23%

Procedure

Following the amide coupling procedure described in protocol A, 500 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.0 mmol), 356 mg CDI (2.2 mmol) and 468 mg 6-amino-1-hexanol (4.0 mmol) yielded 161 mg of 6-hydroxy-N-(6-hydroxyhexyl)-2,5,7,8-tetramethylchroman-2-carboxamide as a white solid.

Sources & evidence

ORD record
ord-012e860874674453a37dc7643fc9a0e6
Source dataset
uspto-grants-2011_06
Patent number
US07968746B2

Reaction notes

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