反应详情

A mixture of (5-fluoro-2-nitrophenyl)pyridin-2-yl-amine (3.92 g, 17 mmol) in EtOAc (150 mL) was degassed with a stream of nitrogen prior to addition of 10% Pd/C (500 mg) and was stirred at RT under a hydrogen atmosphere for 18 h. The suspension was filtered through a phase separator and the filtrate concentrated in vacuo to afford the title compound as a black solid (3.5 g, quantitative).

1. customwas degassed with a stream of nitrogen
2. additionto addition of 10% Pd/C (500 mg)
3. filtrationThe suspension was filtered through a phase separator
4. concentrationthe filtrate concentrated in vacuo