反应详情

A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole in 10 mL 2M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours during which time a white solid formed. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

1. customformed
2. filtrationThe precipitate was collected by vacuum filtration
3. washwashed twice with 5 mL of water
4. customdried under vacuum at 40° C. overnight