HCID 68157595, compound → HCID 68157564, compound

HRID 243194Notes

Reaction equation

HRID 243194 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-])=O)=[C:6]([NH:8][C:9]2[N:10]([CH3:14])[N:11]=[CH:12][CH:13]=2)[CH:7]=1>[Pd].CCOC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[N:10]([CH3:14])[N:11]=[CH:12][CH:13]=2)[C:5]([NH2:15])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 68157595HCID 68157595, compound

Product 1

HCID 68157564HCID 68157564, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of (5-fluoro-2-nitrophenyl)-(2-methyl-2H-pyrazol-3-yl)-amine (0.96 g, 4.06 mmol) and 10% palladium on carbon (0.20 g) in EtOAc (40 mL) was stirred under an atmosphere of hydrogen at atmospheric pressure and 20° C. for 5 h. The catalyst was removed by filtration and the filtrate concentrated in vacuo to give the title compound as a white solid (0.63 g, 88%). LCMS (Method C): RT 1.88 min [M+H]+ 207.0

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-9fdddd25cb66401aa285fa5dbb38a49f
Source dataset
uspto-grants-2014_02
Patent number
US08653089B2

Reaction notes

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