Hydrochloric Acid → HCID 68157878, compound

HRID 243271Notes

Reaction equation

HRID 243271 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:12]2[CH:20]=[C:21]([F:24])[CH:22]=[CH:23][C:11]=2[N:10]=1)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[F:24][C:21]1[CH:22]=[CH:23][C:11]2[N:10]=[C:9]([CH2:8][NH2:7])[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:12]=2[CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68157729HCID 68157729, compound

Product 1

HCID 68157878HCID 68157878, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(6-Fluoro-1-phenyl-1H-benzoimidazol-2-ylmethyl)carbamic acid tert-butyl ester (0.265 g, 0.77 mmol) was treated with 4M HCl in dioxan (5 mL) for 45 min at room temperature. The reaction was evaporated to dryness and the residue triturated with diethyl ether to give the title product as a white solid, (226 mg, approx 100%). LCMS (Method B): RT 2.06 min [M+H]+ 241.98

Workup

  1. customThe reaction was evaporated to dryness
  2. customthe residue triturated with diethyl ether

Sources & evidence

ORD record
ord-5973ad8c89b34d178087a3dfd202bfcf
Source dataset
uspto-grants-2014_02
Patent number
US08653089B2

Reaction notes

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