Trifluoroacetic acid → HCID 59442801, compound

HRID 243555Notes

Reaction equation

HRID 243555 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]2[O:20][CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH:15]2[O:20][CH2:19][CH2:18][NH:17][CH2:16]2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59442799HCID 59442799, compound

Product 1

HCID 59442801HCID 59442801, compoundYield 225%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-((4-benzylpiperazin-1-yl)methyl)morpholine-4-carboxylate (600 mg) in CH2Cl2 (10 ml) is added trifluoroacetic acid (1.8 ml), and the mixture is stirred over night. The solvent is removed under reduced pressure to give 2-((4-benzylpiperazin-1-yl)methyl)morpholine*3 TFA (990 mg).

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-bca997268e0d4f43b9c58ab7126a3248
Source dataset
uspto-grants-2014_02
Patent number
US08653262B2

Reaction notes

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