Aluminium lithium hydride → HCID 56652279, compound

HRID 243628Notes

Reaction equation

HRID 243628 reaction equation
C[O:2][C:3]([C@@H:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][C:8]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:7]=2[C@H:6]1[CH2:21][N+:22]([O-])=O)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1.C1(C)C=CC=CC=1>C1COCC1>[NH2:22][CH2:21][C@H:6]1[C@H:5]([CH2:3][OH:2])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][C:8]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:7]1=2

Participants

5

Reactant 3

HCID 21226445Aluminium lithium hydrideHCID 22635083Tetrahydrofuran tolueneHCID 66920946HCID 66920946, compound

Product 1

HCID 56652279HCID 56652279, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of trans-2-Chloro-11-nitromethyl-10,11-dihydro-dibenzo[b,f]oxepine-10-carboxylic acid methyl ester (4) (4.6 g, 13.23 mmol) in dry THF (23 ml) is added at—15° C. to a mixture of THF (23 ml) and 3.5 M Lithium aluminum hydride (LAH) suspension in THF/Toluene (15.1 ml, 52.9 mmol).

Sources & evidence

ORD record
ord-caf5f02d5b5d422089271bfb59d2d112
Source dataset
uspto-grants-2014_02
Patent number
US08653280B2

Reaction notes

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