反应详情

温度

150 °C

A mixture of 5-methylisatin (15.0 g) and 60 ml of hydrazine hydrate was stirred at 140-160° C. for 4 hours. The reaction mixture was cooled to room temperature, poured into 300 ml of ice water and acidified to pH 2 with 6 N hydrochloric acid. After standing at room temperature for 2 days, a precipitate formed which was collected by vacuum filtration, washed with water and dried under vacuum to give 6.5 g (47% yield) of 5-methyl-2-oxindole.

1. temperatureThe reaction mixture was cooled to room temperature
2. waitAfter standing at room temperature for 2 days
3. customa precipitate formed which
4. filtrationwas collected by vacuum filtration
5. washwashed with water
6. customdried under vacuum