Benzaldehyde → HCID 11965522, compound

HRID 244590Notes

Reaction equation

HRID 244590 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:24])=[C:8]([NH:10][C:11]2[O:12][C:13]([C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:14][N:15]=2)[CH:9]=1)(=[O:3])[CH3:2].[CH:25](=O)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[OH-].[Na+]>C(O)C>[CH3:24][C:7]1[CH:6]=[CH:5][C:4]([C:1](=[O:3])[CH2:2][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:9][C:8]=1[NH:10][C:11]1[O:12][C:13]([C:16]2[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=2)=[CH:14][N:15]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 14798Sodium HydroxideHCID 11965520HCID 11965520, compound

Product 1

HCID 11965522HCID 11965522, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 4-[2-(5-Acetyl-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile (100 mg, 0.315 mmol) and benzaldehyde (0.035 mL, 0.35 mmol) in ethanol, was added dropwise at 0° C., 1 mL of aqueous NaOH 30%. After the mixture was stirred at room temperature for 16 h and poured into ice water (ca. 10 mL). The precipitate was filtered, washed diethyl ether and dried under vacuum.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed diethyl ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-0f76258ebdf24a9d94aaf5c00fb1fab1
Source dataset
uspto-grants-2014_02
Patent number
US08658659B2

Reaction notes

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