Hydrochloric Acid → HCID 58356364, compound

HRID 244632Notes

Reaction equation

HRID 244632 reaction equation
[CH3:1][CH:2]([N:4]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:7][C:6]([C:16]([O:18]C(C)(C)C)=[O:17])=[N:5]1)[CH3:3].Cl>O1CCOCC1>[CH3:3][CH:2]([N:4]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:7][C:6]([C:16]([OH:18])=[O:17])=[N:5]1)[CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58356368HCID 58356368, compound

Product 1

HCID 58356364HCID 58356364, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1,1-Dimethylethyl 1-(1-methylethyl)-5-(4-morpholinylmethyl)-1H-pyrazole-3-carboxylate (101 mg) was dissolved in 1,4-Dioxane (2 ml). 4M hydrogen chloride in 1,4 dioxane (3 ml) was added and the mixture was stirred at RT under nitrogen for 6 h. The solvent was removed in vacuo, toluene (10 ml) was added and removed in vacuo to give a white solid. The solid was dried in a vacuum oven over-night to give the title compound (81 mg) as a white solid.

Workup

  1. customThe solvent was removed in vacuo, toluene (10 ml)
  2. additionwas added
  3. customremoved in vacuo
  4. customto give a white solid
  5. customThe solid was dried in a vacuum oven over-night

Sources & evidence

ORD record
ord-6c7aeaf58423463188ffa4c2aba7f9d7
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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