反应详情

A suspension of 5-chlorosulfonyl-2-oxindole (3.38 g) in 2M methylamine in tetrahydrofuran (10 mL) was stirred at room temperature for 4 hours at which time a white solid had formed. The solid was collected by vacuum filtration, washed twice with 5 mL of water-and dried under vacuum at 40° C. to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

1. customhad formed
2. filtrationThe solid was collected by vacuum filtration
3. washwashed twice with 5 mL of water-
4. customdried under vacuum at 40° C.