反应详情

1-[(6-Bromo-3-nitroquinolin-4-yl)amino]-2-methylpropan-2-ol (17.2 g, 50.5 mmol), toluene (150 mL) and isopropanol (20 mL) were added to a Parr flask containing 5% platinum on carbon (1.7 g) wetted with toluene. The flask was evacuated three times, charged with hydrogen to 30 psi, and shaken for 72 hours. The reaction mixture was filtered through a pad of CELITE filter agent. The CELITE was washed with several portions of dichloromethane followed by methanol. The filtrate was concentrated to provide crude 1-[(3-amino-6-bromoquinolin-4-yl)amino]-2-methylpropan-2-ol as a brown oil.

1. customThe flask was evacuated three times
2. additioncharged with hydrogen to 30 psi
3. filtrationThe reaction mixture was filtered through a pad of CELITE
4. filtrationfilter agent
5. washThe CELITE was washed with several portions of dichloromethane
6. concentrationThe filtrate was concentrated