反应详情

A mixture of 4-nitro-2-fluorobenzonitrile (1.83 g, 5 mmol) and iron (1.68 g, 6 mmol) M a mixture of acetic acid (40 ml) and ethyl acetate (40 ml) was refluxed for 2 hours. The solid was filtered off and the filtrate was washed with water and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, concentrated and chromatographed (dichloromethane:acetone, 95:5) to yield 4-amino-2-fluorobenzonitrile (54a) (0.653 g, 4.8 mmol, 96%).

1. temperaturewas refluxed for 2 hours
2. filtrationThe solid was filtered off
3. washthe filtrate was washed with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over magnesium sulfate
6. concentrationconcentrated
7. customchromatographed (dichloromethane:acetone, 95:5)