反应详情

(S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (0.3 g, 1 mmol), acetic anhydride (0.12 g, 1.2 mmol) and triethylamine (0.5 g, 5 mmol) were added to 10 mL ethyl acetate and the reaction mixture was stirred at room temperature for 2 hours. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered, most part of the solvent was evaporated, frozen crystallized and filtered to yield the crude product. The crude product was recrystallized with ethyl acetate to provide 0.30 g of linezolid in 88% yield.

1. washThe organic layer was washed with brine
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationfiltered
4. custommost part of the solvent was evaporated
5. temperaturefrozen
6. customcrystallized
7. filtrationfiltered
8. customto yield the crude product
9. customThe crude product was recrystallized with ethyl acetate