反应详情

温度

180 °C

To 1.59 g (5.66 mmol) of 6-amino-7-bromo-quinoline-5-carboxylic acid methyl ester in 30 mL of dioxane under an atmosphere of argon is added 2.35 g (17.0 mmol) of K2CO3, 323 mg (0.28 mmol) of tetrakis(triphenylphsophine)palladium and 710 mg (5.66 mmol) of trimethylboroxine. The reaction mixture is stirred in a microwave oven at 180° C. for 10 minutes. After filtration over Celite and concentration in vacuo, the residue is purified by flash chromatography (SiO2, ethyl acetate) y to afford 550 mg of product (45%) as a yellowish solid; LC/MS:217/218 (M+H)+.

1. filtrationAfter filtration
2. concentrationover Celite and concentration in vacuo
3. customthe residue is purified by flash chromatography (SiO2, ethyl acetate) y