反应详情

温度

110 °C

To a stirred solution of 2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (140 mg, 316 μmol) in toluene (2 mL) was added copper (I) iodide (3.17 mg, 35.4 μmol), sodium iodide (94.7 mg, 631 mmol) and trans-N,N′-dimethylcyclohexane-1,2-diamine (11.5 mg, 80.5 μmol). The reaction mixture was sealed under nitrogen and the mixture heated at 110° C. for 15 h. To the mixture was added 1H-indazole (37.3 mg, 316 μmol) and potassium phosphate tribasic (141 mg, 663 μmol) then the reaction vessel was degassed, filled with nitrogen, and the mixture heated at in sealed tube at 110° C. for 15 h. The mixture was filtered, the cake washed with ethyl acetate, and the filtrate concentrated in vacuo Purification by chromatography (silica, 24 g Analogix column, 0-40% ethyl acetate in hexanes) gave N-(1-Hydroxy-2-methylpropan-2-yl)-2-(1H-indazol-1-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (112 mg, 74%). 1H NMR (CDCl3) d: 9.21 (s, 1H), 8.58 (d, J=8.5 Hz, 1H), 8.35 (s, 1H), 8.30 (s, 1H), 8.01 (s, 1H), 7.87 (d, J=8.1 Hz, 1H), 7.53 (t, J=7.6 Hz, 1H), 7.31-7.41 (m, 1H), 5.73 (s, 2H), 3.81 (s, 2H), 3.55-3.66 (m, 2H), 1.55 (s, 6H), 0.89-1.04 (m, 2H), −0.02 (s, 9H).

1. customThe reaction mixture was sealed under nitrogen
2. customthe reaction vessel was degassed
3. additionfilled with nitrogen
4. temperaturethe mixture heated at in sealed tube at 110° C. for 15 h
5. filtrationThe mixture was filtered
6. washthe cake washed with ethyl acetate
7. concentrationthe filtrate concentrated in vacuo Purification by chromatography (silica, 24 g Analogix column, 0-40% ethyl acetate in hexanes)