Diisopropylethylamine → HCID 71280151, compound

HRID 246580Notes

Reaction equation

HRID 246580 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:12]3[N:17]=[C:16]4[C:18]([C:21](O)=[O:22])=[CH:19][NH:20][C:15]4=[N:14][CH:13]=3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.[CH3:24][C:25]([CH3:44])([Si:27]([CH3:43])([CH3:42])[O:28][CH2:29][C:30]([CH3:41])([NH2:40])[CH2:31][O:32][Si:33]([CH3:39])([CH3:38])[C:34]([CH3:37])([CH3:36])[CH3:35])[CH3:26].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:12]3[N:17]=[C:16]4[C:18]([C:21]([NH:40][C:30]([CH3:41])([CH2:29][O:28][Si:27]([CH3:43])([CH3:42])[C:25]([CH3:44])([CH3:26])[CH3:24])[CH2:31][O:32][Si:33]([CH3:38])([CH3:39])[C:34]([CH3:37])([CH3:36])[CH3:35])=[O:22])=[CH:19][NH:20][C:15]4=[N:14][CH:13]=3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 712796392-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acidHCID 86677993HCID 86677993, compound

Product 1

HCID 71280151HCID 71280151, compoundYield 46.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid (70 mg, 0.225 mmol), 2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecan-6-amine (112 mg, 0.338 mmol), HATU (171 mg, 0.45 mmol) and DIPEA (58 mg, 0.45 mmol) in DMF (5 mL) was stirred at room temperature for 16 hours. The mixture was poured into water (5 mL) and extracted with EtOAc (3×10 mL). The combined organic layers were washed with brine and dried over Na2SO4. After filtration and concentration, the residue was purified by column chromatography on silica gel eluting with petroleum ether/EtOAc (1:1, v/v) to give 2-(6-fluoro-1-methyl-1H-indazol-3-yl)-N-(2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecan-6-yl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide (65 mg, 46%) as a white solid. 1H NMR (300 MHz, DMSO): δ 9.00 (s, 1H), 8.44-8.40 (m, 1H), 8.38 (s, 1H), 7.91 (s, 1H), 7.87 (dd, J=10.2, 2.7 Hz, 1H), 7.06-7.05 (m, 1H), 4.13 (s, 3H), 3.92-3.84 (m, 1H), 1.43 (s, 3H), 0.64 (s, 18H), 0.01 (s, 12H).

Workup

  1. extractionextracted with EtOAc (3×10 mL)
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationAfter filtration and concentration
  5. customthe residue was purified by column chromatography on silica gel eluting with petroleum ether/EtOAc (1:1

Sources & evidence

ORD record
ord-86122b961d1b402ca9dd6478da07f9d5
Source dataset
uspto-grants-2014_02
Patent number
US08658646B2

Reaction notes

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