Methyl iodide → HCID 20162056, compound

HRID 246798Notes

Reaction equation

HRID 246798 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].CI.[Cl:9][C:10]1([C:15]([OH:17])=[O:16])[CH2:12][C:11]1([Cl:14])[Cl:13]>CN(C)C(=O)C>[Cl:9][C:10]1([C:15]([O:17][CH3:1])=[O:16])[CH2:12][C:11]1([Cl:14])[Cl:13]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 14299770HCID 14299770, compound

Product 1

HCID 20162056HCID 20162056, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Potassium carbonate (4.14 grams) and methyl iodide (3.74 ml) were added to a solution of 1,2,2-trichlorocyclopropane carboxylic acid (5.68 grams) and N,N-dimethylacetamide (50 ml). The reaction mixture was stirred for approximately 20 hours and then filtered. Ethyl ether (250 ml) was added to the filtrate and the resultant mixture was washed, dried, and evaporated in vacuo to the desired product, methyl 1,2,2-trichlorocyclopropane carboxylate. Structure of the product was confirmed by NMR.

Workup

  1. filtrationfiltered
  2. additionEthyl ether (250 ml) was added to the filtrate
  3. washthe resultant mixture was washed
  4. customdried
  5. customevaporated in vacuo to the desired product, methyl 1,2,2-trichlorocyclopropane carboxylate

Sources & evidence

ORD record
ord-42f238a7495542028547310e3b96da5e
Source dataset
uspto-grants-1987_11
Patent number
US04704156

Reaction notes

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