反应详情

n-Butylsulfonoyl chloride (6.67 g) in THF (50 ml) is added dropwise to a stirred solution of the carbamate compound of Step 1. above (95 g) and triethylamine (4 g) in THF (160 ml) cooled to -78° C. The reaction mixture is warmed to RT, stirred overnight, poured into H2O and extracted with diethyl ether. The diethyl ether extract is washed, dried, filtered and evaporated, and the residue flash chromatographed (silica gel) affording the desired product in purified form.

1. extractionextracted with diethyl ether
2. extractionThe diethyl ether extract
3. washis washed
4. customdried
5. filtrationfiltered
6. customevaporated
7. customthe residue flash chromatographed (silica gel)