Hydrochloric Acid → Ethyl 5-[5-(3-phenylpropyl)thiophen-2-yl]pentanoate

HRID 247091Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[S:14][C:13]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:23](O)[CH3:24]>>[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[S:14][C:13]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:23][CH3:24])=[O:20])=[CH:12][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 208926Eprovafen

Product 1

HCID 15667456Ethyl 5-[5-(3-phenylpropyl)thiophen-2-yl]pentanoate

Procedure

3 g of 5-[5-(3-phenylpropyl)-thien-2-yl]-valeric acid are dissolved in 10 ml of ethanol and the solution is saturated with HCl gas. The solution is stirred at room temperature for 24 hours and concentrated in vacuo. Purification by column chromatography (silica gel/hexane/ethyl acetate).

Workup

concentrationconcentrated in vacuo
customPurification by column chromatography (silica gel/hexane/ethyl acetate)

Sources & evidence

ORD record: ord-0fcece9982ff482b8168ceb731d814e4
Source dataset: uspto-grants-1987_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04705802

Reaction notes

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