Cyanoacetic acid → HCID 10420253, compound

HRID 247106Notes

Reaction equation

HRID 247106 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=O.[C:11]([CH2:13]C(O)=O)#[N:12]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])/[CH:5]=[CH:13]\[C:11]#[N:12]

Participants

4

Reactant 2

HCID 9740Cyanoacetic acidHCID 227103,4-Dichlorobenzaldehyde

Product 1

HCID 10420253HCID 10420253, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3,4-Dichlorobenzaldehyde (175 gms; 1 m), cyanoacetic acid (100 g; 1.15 m), and pyridine were refluxed for one day. Evaporation produced an oil which was fractionally distilled using a column (1 ft. long, 1/2 inch diameter) filled with glass helices. Overall yield 88.9 g (45%; 30% cis/70% trans).

Workup

  1. customEvaporation
  2. customproduced an oil which
  3. distillationwas fractionally distilled
  4. addition1/2 inch diameter) filled with glass helices

Sources & evidence

ORD record
ord-2750bfde915f49bcb6633668d5626cca
Source dataset
uspto-grants-1987_11
Patent number
US04705807

Reaction notes

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