反应详情

A stirred mixture of 343 mg of 5-(2-amino-1-propenyl)-3-chloromethyl-1,2,4-thiadiazole, 316 mg of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole and 273 mg of 3-nitrobenzaldehyde in 5 ml of isopropyl alcohol was heated under reflux for 10 hours. The mixture was concentrated in vacuo and the residue was chromatographed on silica gel using benzene-ethyl acetate (5:1) as eluent to give 134 mg of 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-5-(3-chloromethyl-1,2,4-thiadiazol-5-yl)-4-(3-nitrophenyl)pyridine.

1. temperaturewas heated
2. temperatureunder reflux for 10 hours
3. concentrationThe mixture was concentrated in vacuo
4. customthe residue was chromatographed on silica gel