3-Methoxyaniline → (3Z)-3-[(3-methoxyanilino)-phenylmethylidene]-1H-indol-2-one

HRID 24730Notes

Reaction equation

HRID 24730 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](Cl)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:21])(=O)C.[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)[NH2:27].[OH-].[Na+]>C1COCC1>[CH3:22][O:23][C:24]1[CH:25]=[C:26]([NH:27]/[C:13](=[C:6]2\[C:5](=[O:21])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 108243-MethoxyanilineHCID 14798Sodium HydroxideHCID 697436571-Acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone

Product 1

HCID 178491075(3Z)-3-[(3-methoxyanilino)-phenylmethylidene]-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 2 from 1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone and 3-methoxyaniline in THF and subsequent treatment with sodium hydroxide solution.

Sources & evidence

ORD record
ord-318a4454c4ab4a2498939cde2b72a4cc
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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