Sodium Hydroxide → HCID 178494500, compound

HRID 24732Notes

Reaction equation

HRID 24732 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](Cl)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:21])(=O)C.Cl.[CH3:23][O:24][CH2:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29].[OH-].[Na+]>C1COCC1.CO>[CH3:23][O:24][CH2:25][C:26]1[CH:27]=[C:28]([NH:29]/[C:13](=[C:6]2\[C:5](=[O:21])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:30]=[CH:31][CH:32]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 225695513-Methoxymethyl-aniline-hydrochlorideHCID 697436571-Acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone

Product 1

HCID 178494500HCID 178494500, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 2 from 1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone and 3-methoxymethyl-aniline-hydrochloride in THF and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-48b6d2d452b74375a4e06cb6cdb23a9b
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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