反应详情

3 g (0.019 mole) of 4-(4-piperidyl)-1H-imidazole and 2.88 g (0.019 mole) of para-fluoropropiophenone are stirred in 70 cm3 of dimethylformamide for 5 minutes. 4 g (0.037 mole) of disodium carbonate and 0.2 g (0.0012 mole) of potassium iodide are added and the solution is brought to 160° C. for 3 hours. After being cooled, the solution is poured into 200 cm3 of water and stirred for 1 hour. The precipitate formed is drained, washed with water, dried and recrystallized in acetonitrile.

1. temperatureAfter being cooled
2. customThe precipitate formed
3. washwashed with water
4. customdried
5. customrecrystallized in acetonitrile