Potassium Iodide → HCID 178458489, compound

HRID 247401Notes

Reaction equation

HRID 247401 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH2:3][CH2:2]1.F[C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:22])[CH2:20][CH3:21])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CN(C)C=O.O>[C:19]([C:16]1[CH:17]=[CH:18][C:13]([N:1]2[CH2:2][CH2:3][CH:4]([C:7]3[N:8]=[CH:9][NH:10][CH:11]=3)[CH2:5][CH2:6]2)=[CH:14][CH:15]=1)(=[O:22])[CH2:20][CH3:21]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 680044-FluoropropiophenoneHCID 1784208734-(1H-imidazol-4-yl)piperidine

Product 1

HCID 178458489HCID 178458489, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

3 g (0.019 mole) of 4-(4-piperidyl)-1H-imidazole and 2.88 g (0.019 mole) of para-fluoropropiophenone are stirred in 70 cm3 of dimethylformamide for 5 minutes. 4 g (0.037 mole) of disodium carbonate and 0.2 g (0.0012 mole) of potassium iodide are added and the solution is brought to 160° C. for 3 hours. After being cooled, the solution is poured into 200 cm3 of water and stirred for 1 hour. The precipitate formed is drained, washed with water, dried and recrystallized in acetonitrile.

Workup

  1. temperatureAfter being cooled
  2. customThe precipitate formed
  3. washwashed with water
  4. customdried
  5. customrecrystallized in acetonitrile

Sources & evidence

ORD record
ord-f87d3afad9354b5ab91c144186471252
Source dataset
uspto-grants-1987_11
Patent number
US04707487

Reaction notes

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